TFRC ELISA Kit for Human(Homo sapiens) | EIAab.comTFRC ELISA Kit for Human(Homo sapiens)

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TFRC (Gene name),

Transferrin receptor protein 1 (Protein name ), TFR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

TFRC;

Protein name:

Transferrin receptor protein 1(TR;TfR;TfR1;Trfr);

Alternative:

p90;T9;

CD:

CD71;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.

Function:

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Subcellular Location:

Transferrin receptor protein 1, serum form Secreted

Protein Attributes:

Sequence length:

760

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

760:

GDVWDIDNEF |

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000353224

String:

P02786

KEGG:

hsa:7037

SMR:

P02786

Pfam:

PF02225

UniGene:

Hs.529618

MIM:

190010

Uniprot:

P02786

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ELISA Kit for Human TR

Cat.:

E0809h

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96T

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ELISA Kit for Human TR

Cat.:

E0809p

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96T

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ELISA Kit for Human TR

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E0809m

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96T

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ELISA Kit for Human TR

Cat.:

E0809r

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96T

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ELISA Kit for Human TR

Cat.:

E0809c

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96T

ELISA Kit for Human TR

Cat.:

E0809d

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96T

CLIA Kit for Human TR

Cat.:

U0809c

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96T

CLIA Kit for Human TR

Cat.:

U0809p

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96T

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CLIA Kit for Human TR

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U0809h

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96T

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CLIA Kit for Human TR

Cat.:

U0809r

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96T

CLIA Kit for Human TR

Cat.:

U0809d

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96T

CLIA Kit for Human TR

Cat.:

U0809m

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96T

Polyclonal Antibody for Human TR

Cat.:

P0809Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human TR

Cat.:

P0809Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human TR

Cat.:

P0809Rb-h

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Monoclonal Antibody for Human TR

Protein for Human TR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathway"

Qiurong Ding, Zhenzhen Wang and Yan Chen

From:Cell Research

References

1.

"Primary structure of human transferrin receptor deduced from the mRNA sequence."
Schneider C. , Owen M.J. , Banville D. , Williams J.G.
Nature311:675-678(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-142
2.

"The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence."
McClelland A. , Kuhn L.C. , Ruddle F.H.
Cell39:267-274(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-142
3.

"Exon/intron structure of the human transferrin receptor gene."
Evans P. , Kemp J.
Gene199:123-131(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
4.

"Molecular and evolutionary studies of the transferrin receptor."
Wheeler D.L.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
5.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
6.

NIEHS SNPs program
Submitted (2006-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Eye.
9.

"Serum transferrin receptor is a truncated form of tissue receptor."
Shih Y.J. , Baynes R.D. , Hudson B.G. , Flowers C.H. , Skikne B.S. , Cook J.D.
J. Biol. Chem.265:19077-19081(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 101-119 (STFR)
10.

"Characterization of transferrin receptor released by K562 erythroleukemia cells."
Baynes R.D. , Shih Y.J. , Hudson B.G. , Cook J.D.
Proc. Soc. Exp. Biol. Med.197:416-423(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 101-123 (STFR);CHARACTERIZATION
tissue: Erythroleukemia.
11.

"Identification of a novel form of the alpha 3 integrin subunit: covalent association with transferrin receptor."
Coppolino M. , Migliorini M. , Argraves W.S. , Dedhar S.
Biochem. J.306:129-134(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 288-302; 694-708 AND 721-730
tissue: Prostatic carcinoma.
12.

"Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size."
Chicz R.M. , Urban R.G. , Lane W.S. , Gorga J.C. , Stern L.J. , Vignali D.A.A. , Strominger J.L.
Nature358:764-768(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 680-696
13.

"Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site."
Rothenberger S. , Iacopetta B.J. , Kuhn L.C.
Cell49:423-431(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Identification of the intermolecular disulfide bonds of the human transferrin receptor and its lipid-attachment site."
Jing S. , Trowbridge I.S.
EMBO J.6:327-331(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-62
15.

"Intermolecular disulfide bonds are not required for the expression of the dimeric state and functional activity of the transferrin receptor."
Alvarez E. , Girones N. , Davis R.J.
EMBO J.8:2231-2240(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYSTEINE RESIDUES INVOLVED IN INTERMOLECULAR BONDS
16.

"A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis."
Alvarez E. , Girones N. , Davis R.J.
Biochem. J.267:31-35(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-20
17.

"Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization."
Jing S. , Spencer T. , Miller K. , Hopkins C. , Trowbridge I.S.
J. Cell Biol.110:283-294(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERNALIZATION SEQUENCE;MUTAGENESIS OF TYR-20
18.

"Presence of O-linked oligosaccharide on a threonine residue in the human transferrin receptor."
Do S.-I. , Cummings R.D.
Glycobiology2:345-353(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-104
19.

"Identification of the O-linked glycosylation site of the human transferrin receptor."
Hayes G.R. , Enns C.A. , Lucas J.J.
Glycobiology2:355-359(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-104
20.

"YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis."
Collawn J.F. , Lai A. , Domingo D.L. , Fitch M. , Hatton S. , Trowbridge I.S.
J. Biol. Chem.268:21686-21692(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 20-TYR--PHE-23; TYR-20; THR-21 AND PHE-23
21.

"The critical glycosylation site of human transferrin receptor contains a high-mannose oligosaccharide."
Hayes G.R. , Williams A. , Costello C.E. , Enns C.A. , Lucas J.J.
Glycobiology5:227-232(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CARBOHYDRATES ON ASN-727
22.

"Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding."
Buchegger F. , Trowbridge I.S. , Liu L.F. , White S. , Collawn J.F.
Eur. J. Biochem.235:9-17(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF LIGAND-BINDING DOMAIN
23.

"A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin."
Dubljevic V. , Sali A. , Goding J.W.
Biochem. J.341:11-14(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-646; GLY-647 AND ASP-648
24.

"Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites."
West A.P. Jr. , Giannetti A.M. , Herr A.B. , Bennett M.J. , Nangiana J.S. , Pierce J.R. , Weiner L.P. , Snow P.M. , Bjorkman P.J.
J. Mol. Biol.313:385-397(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
25.

"TTP specifically regulates the internalization of the transferrin receptor."
Tosoni D. , Puri C. , Confalonieri S. , Salcini A.E. , De Camilli P. , Tacchetti C. , Di Fiore P.P.
Cell123:875-888(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH3BP4
26.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-251
tissue: Plasma.
27.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.

"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue: Melanoma.
29.

"Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses."
Radoshitzky S.R. , Abraham J. , Spiropoulou C.F. , Kuhn J.H. , Nguyen D. , Li W. , Nagel J. , Schmidt P.J. , Nunberg J.H. , Andrews N.C. , Farzan M. , Choe H.
Nature446:92-96(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MACHUPO ARENAVIRUS PROTEIN GPC
30.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-21;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
31.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-251 AND ASN-727
tissue: Liver.
32.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-251
tissue: Leukemic T-cell.
33.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
34.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-20;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
35.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
36.

"Structural model of phospholipid-reconstituted human transferrin receptor derived by electron microscopy."
Fuchs H. , Luecken W. , Tauber R. , Engel A.
Structure6:1235-1243(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ELECTRON MICROSCOPY
37.

"Crystal structure of the ectodomain of human transferrin receptor."
Lawrence C.M. , Ray S. , Babyonyshev M. , Galluser R. , Borhani D.W. , Harrison S.C.
Science286:779-782(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 121-760
38.

"Identification of 96 single nucleotide polymorphisms in eight genes involved in iron metabolism: efficiency of bioinformatic extraction compared with a systematic sequencing approach."
Douabin-Gicquel V. , Soriano N. , Ferran H. , Wojcik F. , Palierne E. , Tamim S. , Jovelin T. , McKie A.T. , Le Gall J.-Y. , David V. , Mosser J.
Hum. Genet.109:393-401(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-142

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